Valacyclovir, also known as generic Valtrex, is an oral antiviral drug used to treat and suppress genital herpes, herpes zoster (shingles) and herpes labialis (cold sores). Known hypersensitivity or intolerance to the drug makes it contraindicated. It is also contraindicated to immunocompromised clients such as individuals afflicted with Human Immunodeficiency Virus or with Acquired Immunodeficiency Syndrome and lactating mothers. Use with caution to clients with renal impairment. Safety and efficacy of the medication have not been determined in children though.
Valtrex works by rapidly converting valacyclovir to acyclovir, the latter having the inhibitory activity against herpes simplex virus types 1 and 2 and varicella-zoster virus. It acts by inhibiting replication of viral DNA by competitive inhibition of viral DNA polymerase, incorporation and termination of the growing viral DNA chain, and inactivation of the viral DNA polymerase. Rapidly absorbed after ingestion and is nearly completely converted to acyclovir by first passing through intestinal or hepatic metabolism. Approximately 50% is excreted through the urine.
The drug has notable interactions with other drugs such as cimetidine and probenecid which can decrease the rate, but not the extent, of conversion of valacyclovir to acyclovir. Also, the renal clearance of acyclovir decreases.
Possible side effects from the medication includes
- nausea and vomiting,
- abdominal pain,
- decreased consciousness,
- auditory and visual hallucinations,
- and dyspnea.
Clients experiencing any of the possible side effects must immediately discontinue or stop drug use and alert or report any available health providers such as doctors and nurses.
Valacyclovir can be taken with or without food and a glass of water. Avoid taking antacids since most antacids contain an alkaline base which prevents absorption of the drug. Likewise, the use of hormones like estorgens and oral contraceptives may decrease the effectiveness of the drug. Medication therapy should begin as soon as possible after herpes zoster has been diagnosed. The drug is most effective when started within 48 hour after the onset of rash. For recurrent genital herpes, initiate at the first signs and symptoms of a flare.
It is also important to store the drug at room temperature. An oral therapy for genital herpes, shingles and cold sores has already been made available through the web. Technology lends a hand for making things fast and easy such as ordering Valacyclovir and other therapeutic medications for herpes simplex virus types 1 and 2 and varicella-zoster virus. Ordering Generic Valacyclovir Online helps diminish the psychological trauma brought about by ordering it in pharmacies or drugstores. A client is able to buy quality generic and cheap Valacyclovir. With proper management and responsibility, a client would find that valacyclovir is not just effective but safe as well.